@article{Sana_Umair_Saeed_2021, title={Effect of Nigella sativa on Estradiol Levels and Menopausal Symptoms in Post-Menopausal Females}, volume={35}, url={http://proceedings-szmc.org.pk/index.php/szmc/article/view/183}, DOI={10.47489/PSZMC-815354-36-40}, abstractNote={<p><strong>Introduction: </strong>Menopause is the permanent cessation of menses, typically occurs in women of 45-55 years. Menopause is associated with a number of somatic, psychological and sexual symptoms due to decline in estradiol levels resulting in poor quality of life of postmenopausal females.</p> <p><strong>Aims & Objectives:</strong> The purpose of the current study was to determine the effect of <em>Nigella sativa</em> on menopausal symptoms and estradiol levels in postmenopausal females.</p> <p><strong>Place and duration of study: </strong>Department of Physiology PGMI, Lahore for 8 weeks.</p> <p><strong>Material & Methods: </strong>It was an interventional study conducted on 30 postmenopausal females<strong>. </strong><em>Nigella sativa</em> was administered in the dose of 1g/day after breakfast for a period of 8 weeks. Menopausal Rating Scale (MRS) was filled and blood sample was taken before and after giving <em>Nigella sativa</em> for estradiol and testosterone levels. Data was analyzed by paired t-test using SPSS-21 and p- value less than 0.05 was considered significant.</p> <p><strong>Results: </strong>The result of the study showed that there was statistically significant reduction in the overall score of MRS (p = 0.001) and in all its domains, somatic (p=0.001), psychological (p=0.001) and urogenital (p=0.017). There was also significant improvement in blood estradiol level after 8 weeks of <em>Nigella sativa</em> administration (p= 0.021).</p> <p><strong>Conclusion: </strong><em>Nigella sativa</em> supplementation increases estradiol level and decreases menopausal symptoms severity as indicted by significant reduction in the 3 domains of MRS and may be used by postmenopausal females on regular basis to improve their quality of life.</p>}, number={4}, journal={Proceedings}, author={Sana, Shazo and Umair, Hafiz Muhammad and Saeed, Muniza}, year={2021}, month={Nov.}, pages={36–40} }