@article{Hajra Farooq_Omar Rasheed Chughtai_Hijab Batool_Waheed uz Zaman Tariq_Akhtar Sohail Chughtai_2021, title={Comparison of Covid-19 IgG Anti-Spike Antibody Titer after Vaccination with Sputnik V in Seropositive and Naïve Vaccinees }, volume={35}, url={https://proceedings-szmc.org.pk/index.php/szmc/article/view/177}, DOI={10.47489/PSZMC-815354-1-5}, abstractNote={<p><strong>Introduction: </strong>Immunity to SARS-CoV-2 has shown to reduce the risk of having a severe infection and initiate a good degree of disease protection. <strong>S</strong>tudies assessing the antibody titer after vaccination can be very helpful to see whether previously infected individuals have better immunological response as compared to uninfected or antibody naïve individuals. <strong> </strong></p> <p><strong>Aims & Objectives: </strong>Comparison of Anti-spike IgG antibody among vaccinees with or without previous exposure to COVID-19. To determine whether single dose regimen can produce significant antibody titer amongst previously infected cases and design vaccine dosage regimens accordingly.</p> <p><strong>Place and duration of study: </strong>This study was conducted at Chughtai Institute of Pathology from April 2021 to June 2021.</p> <p><strong>Material & Methods: </strong>Blood samples were collected from 83 adult male and female vaccinees at baseline, 3 weeks after the first dose and finally 7 days after the second dose. Previously infected individuals’ record was noted separately. Samples were immediately analyzed using Abbott SARS-CoV-2 IgG II quant two step immunoassay. Data was analyzed using SPSS 23.0. A p-value of <0.05 was considered significant.</p> <p><strong>Results: </strong>Majority of the candidates (57 %) were females and on analysis it was found that 42% of the patients were seropositive whereas 58% of the patients were antibody naïve before receiving the first dose of vaccine.  There was a significant difference between mean antibody titer of seropositive and seronegative study participants at day 0, day 21 and finally on day 28 (p value <0.001) with seropositive individuals having higher antibody titers even after first vaccine shot.</p> <p><strong>Conclusion: </strong>Post vaccination immunological response was higher in seropositive individuals as compared to the antibody naïve and this finding can help the policy makers to design a single dose vaccine regimen for the former</p>}, number={4}, journal={Proceedings}, author={Hajra Farooq and Omar Rasheed Chughtai and Hijab Batool and Waheed uz Zaman Tariq and Akhtar Sohail Chughtai}, year={2021}, month={Nov.}, pages={1–5} }