Effect of Nigella sativa on Estradiol Levels and Menopausal Symptoms in Post-Menopausal Females

Authors

  • Shazo Sana Department of Physiology, Fatima Jinnah Medical University, Lahore
  • Hafiz Muhammad Umair Department of Hematology, Fatima Jinnah Medical University, Lahore
  • Muniza Saeed

DOI:

https://doi.org/10.47489/PSZMC-815354-36-40

Keywords:

Nigella sativa, menopausal symptoms, estradiol level.

Abstract

Introduction: Menopause is the permanent cessation of menses, typically occurs in women of 45-55 years. Menopause is associated with a number of somatic, psychological and sexual symptoms due to decline in estradiol levels resulting in poor quality of life of postmenopausal females.

Aims & Objectives: The purpose of the current study was to determine the effect of Nigella sativa on menopausal symptoms and estradiol levels in postmenopausal females.

Place and duration of study: Department of Physiology PGMI, Lahore for 8 weeks.

Material & Methods: It was an interventional study conducted on 30 postmenopausal females. Nigella sativa was administered in the dose of 1g/day after breakfast for a period of 8 weeks. Menopausal Rating Scale (MRS) was filled and blood sample was taken before and after giving Nigella sativa for estradiol and testosterone levels. Data was analyzed by paired t-test using SPSS-21 and p- value less than 0.05 was considered significant.

Results: The result of the study showed that there was statistically significant reduction in the overall score of MRS (p = 0.001) and in all its domains, somatic (p=0.001), psychological (p=0.001) and urogenital (p=0.017). There was also significant improvement in blood estradiol level after 8 weeks of Nigella sativa administration (p= 0.021).

Conclusion: Nigella sativa supplementation increases estradiol level and decreases menopausal symptoms severity as indicted by significant reduction in the 3 domains of MRS and may be used by postmenopausal females on regular basis to improve their quality of life.

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Published

2021-11-08

How to Cite

1.
Sana S, Umair HM, Saeed M. Effect of Nigella sativa on Estradiol Levels and Menopausal Symptoms in Post-Menopausal Females. Proceedings S.Z.M.C [Internet]. 2021Nov.8 [cited 2023Feb.1];35(4):36-40. Available from: http://proceedings-szmc.org.pk/index.php/szmc/article/view/183