Prevalence of Secondary Hyperparathyroidism in Hemo- Dialysis Patients


  • Awais Amjad Department of Physiology, CMH Kharian Medical College, Kharian.
  • Mateen Akram Department of Nephrology, Sheikh Zayed Hospital, Lahore.
  • Rana Muhammad Umar Department of Nephrology, Sheikh Zayed Hospital, Lahore.
  • Aiman Farogh Anjum Department of Physiology, CMH Kharian Medical College, Kharian.
  • Saba Izhar Department of Medicine, CMH Kharian Medical College, Kharian.



Chronic kidney disease, hemo-dialysis, parathyroid hormone, Secondary hyperparathyroidism


Introduction: One persistent complication of chronic kidney disease is secondary hyperparathyroidism. Early diagnosis of this disease will reduce morbidity in patients undergoing hemodialysis.

Aims & Objectives: To determine the prevalence of secondary hyperparathyroidism in chronic kidney disease patients at National Institute of Kidney Diseases, SZH Lahore.

Place and Duration of Study: A cross sectional study was conducted at Nephrology Department of Shaikh Zayed Hospital (SZH) Lahore after getting approval from Institutional Review Board of National Health Research Complex (NHRC). It was conducted from September 2023 to November 2023 &140 hemo-dialysis patients were selected.

Material & Methods: We measured serum parathyroid hormone, hemoglobin and other variables, at Biochemistry laboratory of Sheikh Zayed Hospital, in 140 hemodialysis patients. Serum samples were measured for PTH levels using ELISA method. The data was analyzed using SPSS version 20.P value ? 0.05 was considered significant.

Results: Fifteen patients had secondary hyperparathyroidism out of 140 hemodialysis patients. Hyperparathyroidism was observed in 10.71 % of the patients. Hyperparathyroidism patients had significantly low calcium, hemoglobin levels & higher phosphate levels.

Conclusion: The prevalence of secondary hyperparathyroidism is low at 10.71% of patients undergoing hemodialysis at National Institute of Kidney Disease, SZH Lahore.


Rodríguez-Ortiz ME, Rodríguez M. Recent advances in understanding and managing secondary hyperparathyroidism in chronic kidney disease. F1000Research.2020;9. 00research.22636.1

Hyder R, Sprague SM. Secondary Hyperparathyroidism in a Patient with CKD. Clin J Am Soc Nephrol. 2020;15(7):1041-3.

van der Plas WY, Noltes ME, van Ginhoven TM, Kruijff S. Secondary and Tertiary Hyperparathyroidism: A Narrative Review. Scand J Surg.2020;109(4):2718. 496919866015.

Komaba H, Zhao J, Yamamoto S, Nomura T, Fuller DS, McCullough KP, et al. Secondary hyperparathyroidism, weight loss, and longer term mortality in haemodialysis patients: results from the DOPPS. J Cachexia Sarcopenia Muscle. 2021;12(4):85565. 2.

Habas E, Sr., Eledrisi M, Khan F, Elzouki AY. Secondary Hyperparathyroidism in Chronic Kidney Disease: Pathophysiology and Management. Cureus.2021;13(7):e16388. ureus.16388

Brandenburg V, Ketteler M. Vitamin D and Secondary Hyperparathyroidism in Chronic Kidney Disease: A Critical Appraisal of the Past, Present, and the Future. Nutrients. 2022;14(15):3009. 09

Bargagli M, Arena M, Naticchia A, Gambaro G, Mazzaferro S, Fuster D, et al. The Role of Diet in Bone and Mineral Metabolism and Secondary Hyperparathyroidism.Nutrients2021;13(7):2328.http s://

Gimba ZM, Abene EE, Agbaji OO, Agaba EI. Secondary hyperparathyroidism among Nigerians with chronic kidney disease. African health sciences.2018;18(2):44657. hs.v18i2.30

Arbor Research Collaborative for Health, Dialysis Outcomes Practice Patterns Study (DOPPS) Practice Monitor, Available from: Accessed January 2019.

Assumpção LR, de Paula Ramos I, Nunes da Cunha G, de Mello Vianna CM, Araújo Maya MC, Araújo DV. Refractory secondary hyperparathyroidism in waiting list for parathyroidectomy: who we should operate first in a quaternary hospital in Brazil regarding survival. Renal Failure. 2019;41(1):183- 9.

Sonkar SK, Singh HP, Sonkar GK, Pandey S. Association of Vitamin D and secondary hyperparathyroidism with anemia in diabetic kidney disease. J Family Med Prim Care. 2018;7(4):815- 8.

Zhang LX, Zhang B, Liu XY, Wang ZM, Qi P, Zhang TY, et al. Advances in the treatment of secondary and tertiary hyperparathyroidism. Front Endocrinol(Lausanne).2022;13:1059828.https://doi. org/ 10.3389/fendo.2022.1059828.

Reichel H, Seibert E, Tillmann FP, Barck I, Grava A, Schneider KM, et al. Economic burden of secondary hyperparathyroidism in Germany: a matched comparison. Int Urol Nephrol. 2023;55(5):1291300.




How to Cite

Amjad A, Mateen Akram, Rana Muhammad Umar, Aiman Farogh Anjum, Saba Izhar. Prevalence of Secondary Hyperparathyroidism in Hemo- Dialysis Patients. Proceedings S.Z.M.C [Internet]. 2024 Feb. 2 [cited 2024 Apr. 24];38(1):42-4. Available from: