Grape Seed Extract Affects Body Weight, Liver Weight and Relative Tissue Weight Index in Aluminium Chloride Treated Rats

Authors

  • Sadia Iqbal Deparment of Anatomy, Allama Iqbal Medical College, Lahore.
  • Muhammad Suhail Department of Anatomy, Amna Inayat Medical College, Sheikhupura.
  • Ahmad Haris Suhail Consultant Anesthetist, Integrated Medical Care Complex D.H.A, Lahore.
  • Faiza Rauf Department of Anatomy, Rashid Latif Khan Medical College, Lahore.
  • Faiza Shafqat Department of Anatomy, Islamabad Medical & Dental College, Islamabad.
  • Maria Illyas Deparment of Anatomy, Allama Iqbal Medical College, Lahore.

DOI:

https://doi.org/10.47489/szmc.v38i1.446

Keywords:

Grape seed extract, Aluminum Chloride, Vitis venifera, Body weight, Liver weight

Abstract

Introduction: Grape seed extract (vitis vinifera) contains antioxidant compounds with ability to prevent aluminium chloride induced hepatotoxicity.

Aims & Objectives: To study the effects of grape seed extract on body weight, liver weight and relative tissue weight index in aluminium chloride treated rats.

Place and Duration of Study: This experimental study study was conducted at the Animal House of Post Graduate Medical Institute, Lahore. Duration of study was February 2017 to February 2018.

Material & Methods: 24 adult, healthy albino rats (male) were divided in to three groups. Group A was given distilled water by gavage (1ml/day), Group B was given aluminium chloride (34mg/kg body weight) and group C was given aluminium chloride plus grape seed extract (34mg/kg and 200 mg/kg body weight) by gavage. Whole treatment continued for 42 days. Statistical Package for Social Sciences (SPSS) version 21 was used for entering and analyzing data.p value of ? 0.05 was considered significant.

Results: A significant difference in body weights of Group B and C rats was noted at the end of the study. Mean liver weight was significantly reduced in aluminium treated group and near normal restoration of liver weight was seen in group C receiving grape seed extract.

Conclusion: Excessive aluminium chloride exposure led to a reduction in body weight, and liver weight. Grape seed extract being an antioxidant improved these effects.

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Published

2024-01-31

How to Cite

1.
Iqbal S, Muhammad Suhail, Suhail AH, Rauf F, Shafqat F, Illyas M. Grape Seed Extract Affects Body Weight, Liver Weight and Relative Tissue Weight Index in Aluminium Chloride Treated Rats. Proceedings S.Z.M.C [Internet]. 2024 Jan. 31 [cited 2024 May 18];38(1):37-41. Available from: http://proceedings-szmc.org.pk/index.php/szmc/article/view/446