Hematological Parameters in Euthyroid and Hypothyroid Females
Keywords:
Thyroid dysfunction, hypothyroidism, hematological parameters, blood composition, thyroid hormoneAbstract
Introduction: Thyroid hormone is an important metabolic hormone affecting hematological parameters. A variation in the hematological picture is seen in patients with hypothyroidism.
Aims & Objectives: to study the differences in hematological parameters in hypothyroid and euthyroid females.
Place and Duration of Study: A Comparative Cross-sectional study using secondary data was conducted from February 2022 to March 2023 at Muhammad Medical College, Pakistan.
Material & Method: A total of 300 females (20-40 years of age, non-pregnant) were included in the study and based on their thyroid profile, they were divided into two groups, 160 with euthyroid status and another group of 140 with hypothyroidism. Hematological parameters were measured and compared in both groups. Data analysis was performed using Graph Pad Prism 9. A t-test, and one-way ANOVA were applied. The significance threshold is set at P < 0.05.
Results: A significantly increased TSH and decreased T3 and T4 (p = < 0.05) were estimated in hypothyroid females. The hematological parameters in hypothyroid females showed hemoglobin (11.18± 1.66), ESR (32.70± 19.84), MCV (77.02± 6.84), MCH (24.00± 3.03), MHC (26.99± 3.67) and RDW (18.03± 4.56). The difference in hematological parameters between euthyroid and hypothyroid groups was found to be statistically significant with a P value of <0.001.
Conclusion: Hypothyroidism showed a microcytic and hypochromic blood picture in females.
References
Metabolism and metabolic syndrome. Therapeutic Advances in Endocrinology and Metabolism; 2020;11. doi:10.1177/2042018820917869
Shahid MA, Ashraf MA, Sharma S. Physiology, Thyroid Hormone. [Updated 2023 Jun 5]. In: Stat Pearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK500006/
Eilon Krashin, Agnieszka Piekielko-Witkowska, Martin Ellis, Osnat Ashur-Fabian. Thyroid Hormones and Cancer: A Comprehensive Review of Preclinical and Clinical Studies. Front. Endocrinol., 13 February 2019Sec. Cancer Endocrinology Volume 10 - 2019 | https://doi.org/10.3389/fendo.2019.0005
Chaker L, Razvi S, Bensenor IM, et al. Hypothyroidism. Nat Rev Dis Primers2022, 8, 30. https://doi.org/10.1038/s41572-022-00357-7
Biondi B, Cooper DS. Thyroid hormone therapy for hypothyroidism. Endocrine, 2019, 66, 18–26. https://doi.org/10.1007/s12020-019-02023-7
Merson J. Hypothyroidism. JAAPA. 2018 Dec;31(12):43-44. doi:10.1097/01.JAA.0000547758.46299.d9. PMID: 30489390.
Dannan R, Hajji S, Aljenaee K. Severe primary hypothyroidism in an asymptomatic 19-year-old woman: a case report. J Med Case Reports,2021 15, 108. https://doi.org/10.1186/s13256-021-02677-w
Wang D, Yu S, Ma C, et al. Reference intervals for thyroid-stimulating hormone, free thyroxine, and free triiodothyronine in elderly Chinese persons. Clin Chem Lab Med. 2019 Jun 26;57(7):1044-1052. doi: 10.1515/cclm-2018-1099. PMID: 30496133.
Chiovato L, Magri F, Carlé A. Hypothyroidism in Context: Where We’ve Been and Where We’re Going, Advances in Therapy. 2019;36(Suppl 2):47–58. Published online 2019 Sep 4. doi:10.1007/s12325-019-01080-8 PMCID: PMC6822815 PMID: 31485975
Walsh JP. Thyroid Function across the Lifespan: Do Age-Related Changes Matter? Endocrinol Metab (Seoul). 2022 Apr;37(2):208–219. Published online 2022 Apr 14. doi:10.3803/EnM.2022.1463
Chaker L, Razvi S, Bensenor IM, et al. Hypothyroidism. Nat Rev Dis Primers,2022, 8, 30. https://doi.org/10.1038/s41572-022-00357-7
Sohail R, Yasmin H, Tasneem N, et al. The Prevalence of Subclinical Hypothyroidism During Early Pregnancy in Pakistan: A Cross-Sectional Study Cureus. 2021 Dec;13(12). Published online 2021 Dec 10. doi:10.7759/cureus.20316
Turner J, Parsi M, Badireddy M. Anemia. [Updated 2023 Aug 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK499994/
Moore CA, Adil A. Macrocytic Anemia. [Updated 2022 Jul 11]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK459295/
Ahmed SS, Mohammed AA. Effects of thyroid dysfunction on hematological parameters: Case-controlled study. Annals of Medicine and Surgery,2020, Volume 57,2020, Pages 52-55, ISSN 2049-0801. https://doi.org/10.1016/j.amsu.2020.07.008.
Bashir H, Bhat MH, Farooq R, et al. Comparison of hematological parameters in untreated and treated subclinical hypothyroidism and primary hypothyroidism patients. Med J Islam Repub Iran. 2012 Nov;26(4):172–178. PMCID: PMC3562538 PMID: 23482519
Mishra AK, Anand R, Verma SP, Gupta KK. Study of the impact of subclinical hypothyroidism on iron status and hematological profile. Int J Adv Med. 2018 Apr;5(2):446-451. DOI: http://dx.doi.org/10.18203/2349-3933.ijam20181087
Aparajita S, Manas T, Santasmita P. Red Blood Cell Indices and Hypothyroidism. JK Science 2022;24(3):177-82
Maheshwari KU, Rajagopalan B, Samuel TR. Variations in Hematological Indices in Patients with Thyroid Dysfunction. International Journal of Contemporary Medical Research, 2020, DOI:10.21276/ijcmr.2020.7.1.9
Shetty A, Vijaya C. A study of hematological parameters and their correlation with thyroid hormone status in non-pregnant women of childbearing age. Indian J Pathol Oncol 2019;6(1):102-106
Naser M, Mahfouz K, Rezk A, Adl H. Pattern of blood cell parameters in thyroid dysfunction. Al-Azhar International Medical Journal Article, 2022 8, Volume 3, Issue 1, January, DOI:10.21608/aimj.2022.101495.1617
Arooj A, Rafiq M, Batool Y, et al. Impact of thyroid dysfunction on red cell indices in a Sahiwal Teaching Hospital, Sahiwal. Professional Med J 2022;29(8):1157-1161. https://doi.org/10.29309/TPMJ/2022.29.08.6961
Ganbaatar B, Damdindorj D, et al., 2023. Effect of Thyroid Dysfunction on Complete Blood Count. Medical Research Archives, [online] 11(9). https://doi.org/10.18103/mra.v11i9.4420
Casis O, Echeazarra L, Sáenz-Díez B, et al. Deciphering the roles of triiodothyronine (T3) and thyroid-stimulating hormone (TSH) on cardiac electrical remodeling in clinical and experimental hypothyroidism. J Physiol Biochem. 2024 Feb;80(1):1-9. doi: 10.1007/s13105-023-01000-z. Epub 2023 Nov 29. PMID: 38019451; PMCID: PMC10808292.
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