Is Coriandrum sativum Hypolipidemic in Alloxan Induced Diabetic Rats?

Abstract

Introduction: Diabetes mellitus is a widely recognized metabolic condition. Due to various side effects of currently available medicines, studies have reported the use of many plants in various areas for the traditional management of diabetes.

Aims & Objectives: To determine the effects of Coriandum sativum seeds on lipid profile in diabetic rats.

Place and duration of study: This experimental research was conducted at Physiology Department, Services Institute of Medical Sciences (SIMS), Lahore from August 2013 to January, 2014.

Material & Methods: Ninety rats were randomly distributed into three groups of (n=30) each. Group A was healthy control, group B was disease control and group C was diabetic experimental which was treated with Coriandrum sativum with a single dosage of 250 mg/kg of body weight/day through a gavage tube for 28 days. On next day, 4-5ml blood was collected through heart from each rat. The markers evaluated were high density lipoprotein (HDL), triglycerides, total cholesterol, low density lipoprotein (LDL) and very low density lipoprotein (VLDL). Data was analyzed by using SPSS version16 ,  p value <0.05 was considered significant.

Results: The experimental group showed highly significant (p=0.000) lower levels of serum LDL (25.47±3.90mg/dl), serum cholesterol (100.33±2.81 mg/dl), serum triglyceride (96.97±4.79 mg/dl) and serum VLDL (19.40±0.97 mg/dl) as compared to healthy control and disease control group. The level of serum high density lipoprotein revealed (55.27±3.69 mg/dl) highly significant rise (p=0.000).

Conclusion: Oral administration of Coriandrum sativum has revealed the lipid lowering impacts in alloxan induced diabetic rats.