Diagnostic Significance of Serum Total Bile Acid Levels in Suspected Cases of Obstetric Cholestasis

Authors

  • Hijab Batool Department of Clinical Chemistry and Immunology,Chughtai Institute of Pathology, Lahore
  • Muhammad Dilawar Khan Department of Clinical Chemistry and Immunology,Chughtai Institute of Pathology, Lahore
  • Omar Rasheed Chughtai Director Operations, Chughtai Institute of Pathology, Lahore
  • Shakeel Ashraf Department of Clinical Chemistry and Immunology,Chughtai Institute of Pathology, Lahore

DOI:

https://doi.org/10.47489/p000s342z7461-5mc

Keywords:

Total Bile Acid, Obstetric Cholestasis, pruritus, jaundice

Abstract

Introduction: Intrahepatic Cholestasis of Pregnancy (ICP) is significantly associated with adverse maternal and fetal outcome and therefore accurate diagnosis and timely initiation of therapy is of utmost importance.

Aims & Objectives: To find out the diagnostic significance of serum total bile acid measurement in suspected cases of obstetric cholestasis.

Place and duration of study: It was a cross sectional study conducted in the Department of Clinical Chemistry and Immunology, Chughtai Institute of Pathology from July 2018 to February 2019.

Material & Methods: Two hundred pregnant females whose serum total bile acid (TBA) was determined were included in the study. Pregnant females with cholestasis due to medical reasons other than ICP were excluded from the study. The patients were contacted for relevant clinical details which were recorded on a pre-designed proforma. Data was analyzed using SPSS 23.0. Univariate analysis was done to find out percentages and frequencies.

Results: Mean age of 200 pregnant females was 27 years having Mean TBA value of 32.8 ?mol/L. 63% females were primiparous. 197 (98.5%) patients gave the history of pruritus while 193 (96.5%) patients presented with dark urine. Only 30 patients (15%) gave history of using progesterone during pregnancy. Total Bile acid value was >10 ?mol/L for 84 primiparous and 48 multiparous cases (n=132). There was no significant difference in the mean TBA value on the basis of parity, medication, mode of delivery or presence and absence of itch.

Conclusion: ICP is a multi factorial reversible condition and bile acid estimation plays a major role in correct clinical assessment of patients with obstetric cholestasis.

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Published

2020-12-02

How to Cite

1.
Hijab Batool, Muhammad Dilawar Khan, Omar Rasheed Chughtai, Shakeel Ashraf. Diagnostic Significance of Serum Total Bile Acid Levels in Suspected Cases of Obstetric Cholestasis. Proceedings S.Z.M.C [Internet]. 2020 Dec. 2 [cited 2024 Apr. 24];34(2):16-20. Available from: https://proceedings-szmc.org.pk/index.php/szmc/article/view/28