Investigating the Mechanisms and Therapeutic Applications of Chalcones

Authors

  • Ahsan Ali Khan Nowshera Medical College, Nowshera, Pakistan
  • Muhammad Haris Nowshera Medical College, Nowshera, Pakistan
  • Sobia Haris Nowshera Medical College, Nowshera, Pakistan
  • Farah Deeba Nowshera Medical College, Nowshera, Pakistan
  • Mashal Tamsil Khyber Teaching Hospital, Peshawar, Pakistan
  • Tayaba Basharat Nowshera Medical College, Nowshera, Pakistan
  • Muhammad Jehangir Khan Makka Medical Center, Nowshera, Pakistan

DOI:

https://doi.org/10.47489/szmc.v38i3.560

Keywords:

Chalcones, therapeutic efficacy, mechanisms, analgesic activity

Abstract

Introduction: Chalcones, are a group of organic compounds containing two aromatic rings bridged by a three-carbon -a,

?; unsaturated carbonyl system. This attracted much attention because of their versatility in pharmacological profiles.

Aims & Objectives: To investigate the therapeutic efficacy of a particular chalcone derivative, namely (E)-1-(4- bromophenyl)-3-(4-chlorophenyl) prop-2-ene-1-one.

Place and Duration of Study: It was conducted in the Pharmacology Laboratory of the Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, and the University of Malakand for about one year.

Material & Method: This was a lab-based experimental study. The therapeutic efficacy of a chalcone derivative, (E)-1- (4-bromophenyl)-3-(4-chlorophenyl) prop-2-ene-1-one was assessed through an experiment on pain and inflammation in mice. Claisen-Schmidt condensation reaction and spectroscopic tools were used.

Results: Pharmacological data proved a significant decrease in pain and inflammation as compared to Diclofenac Sodium. Reduction of 75.20% in acetic acid-induced writhing as compared to 84.4% with Diclofenac. After 3 hours, there was 67.08% reduction in edema.

Conclusion: This study provides evidence that chalcone derivatives in moderation may be effective and safer than present-day drugs that address pain and inflammation. This result may need to be further clinically related to potentially translate them in different patient populations in terms of efficacy and safety.

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Published

2024-09-30

How to Cite

1.
Ahsan Ali Khan, Muhammad Haris, Sobia Haris, Farah Deeba, Mashal Tamsil, Tayaba Basharat, Muhammad Jehangir Khan. Investigating the Mechanisms and Therapeutic Applications of Chalcones. Proceedings S.Z.M.C [Internet]. 2024 Sep. 30 [cited 2024 Oct. 7];38(3):185-92. Available from: https://proceedings-szmc.org.pk/index.php/szmc/article/view/560